Sent: Tuesday, October 19, 1999 8:00 AM Subject: BMT Update, T-2 Well sports fans, I enter a new stage today. The nurse came in last night and told me that I would be starting treatments with Cyclosporine today at 4 AM. This drug is an immunosuppressive agent. I was wrong in previously reporting that the chemo and radiation would kill off my immune system. These kill off the stem cells. However, the white blood cells, whole bunches of different kinds of them, are still floating around in my system. This new drug will inactivate them, don't ask me how. Basically, after this happens, I am an open Petri dish, with extremely high risk of infection. The reason for this new drug is to allow my body to accept my brother's stem cells, due in 2 days. There may be some side effects from the Cyclosporine, but I have been lucky to dodge that bullet on almost everything they have thrown into me so far, so cross your fingers. I spent about 12 hours yesterday without being hooked up to the IV cart through my catheters. You cannot imagine what a pleasure it was to be able to walk in the hallway here without my companion. I will be hooked up again and receiving this new drug for two 6-hour periods per day, apparently designed to minimize my sleep disturbance. It was a great relief coming in here on Friday to begin these treatments. The 4+ months of knowing I had a fatal disease took their toll. When treatment began, it was a psychological boost, as I was going from a passive stage of taking it, to a proactive stage of starting to do something about it. The chemo and radiation are bizarre, scary, but necessary steps in winning the battle. They laid the groundwork by wiping out the root cause of my disease. This new step softens up the field, so that the good guys can invade and take over. My excitement is building, but it sure would be nice to get some more sleep. More later today. Dave